Neurodevelopmental conditions such as autism are underpinned by a complex genetic architecture. Complex genetics scales up to atypical organization at the level of the transcriptome and through to macroscale neural systems and heterogeneity in cognition and behavior. So how is the transcriptome different in autism and how does this relate to the underlying complex genetics or the higher levels of neural systems organization or heterogeneity in cognition or behavior? How can we study and model these phenomena in-vivo in living patients with neurodevelopmental conditions?
Relevant Publications
Lombardo, M. V., et al., (2018). Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes. Nature Neuroscience, 21, 1680-1688.
Lombardo, M. V., Courchesne, E., Lewis, N. E., & Pramparo, T (2017). Hierarchical cortical transcriptome disorganization in autism. Molecular Autism, 8, 29.
Lombardo, M. V., et al., (2018). Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder. Molecular Psychiatry, 23, 1001-1013.
Courchesne, E., Pramparo, T., Gazestani, V. H., Lombardo, M. V., Pierce, K., & Lewis, N. E. (2019). The ASD living biology: From cell proliferation to clinical phenotype. Molecular Psychiatry, 24, 88-107.
Lombardo, M. V., et al., (in press). Sex-specific impact of prenatal androgens on social brain default mode subsystems. Molecular Psychiatry. doi:10.1038/s41380-018-0198-y.
Pramparo, T., Lombardo, M. V., Campbell, K., Carter Barnes, C., Marinero, S., Solso, S., Young, J., Mayo, M., Dale, A., Ahrens-Barbeau, C., Murray, S. S., Lopez, L., Lewis, N., Pierce, K., & Courchesne, E. (2015). Cell cycle networks link gene expression dysregulation, mutation and brain maldevelopment in autistic toddlers. Molecular Systems Biology, 11, 841.
Pramparo, T., Pierce, K., Lombardo, M. V., Carter Barnes, C., Marinero, S., Ahrens-Barbeau, C., Murray, S., Lopez, L., Xu, R., & Courchesne, E. (2015). Translation and immune/inflammation co-expressed genes predict autism in infants and toddlers from pediatric community practices. JAMA Psychiatry, 72, 386-394.
