The brain is a multi-scale complex network. Unraveling network organization and disorganization is a key to understanding how variability in human brain and behavior manifests. In this project we use in-vivo neuroimaging techniques to characterize how the connectome is organized in neurodevelopmental conditions such as autism, and how that organization dynamically changes over multiple time-scales.

Relevant Publications

Lombardo, M. V., Eyler, L., Moore, A., Datko, M., Barnes, C. C., Cha, D., Courchesne, E., & Pierce, K. (2019). Default mode-visual network hypoconnectivity in an autism subtype with pronounced social visual engagement difficulties.. eLife, 8, e47427. doi:10.7554/eLife.47427.

Lombardo, M. V., et al., (2020). Sex-specific impact of prenatal androgens on social brain default mode subsystems. Molecular Psychiatry, 25, 2175-2188.

Bethlehem, R, A. I, Lombardo, M. V., et al., (2017). Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women. Translational Psychiatry, 7, e1099.

Ritchie, S. J., Cox, S. R., Shen, X., Lombardo, M. V., et al., (2018). Sex differences in the adult human brain: Evidence from 5,216 UK Biobank participants. Cerebral Cortex, 28, 2959-2975.

Oldehinkel, M., Mennes, M., Marquand, A., Charman, T., Tillmann, J., Ecker, C., Dell’Acqua, F., Brandeis, D., Banaschewski, T., Baumeister, S., Moessnang, C., Baron-Cohen, S., Holt, R., Bölte, S., Durston, S., Kundu, P., Lombardo, M. V., Spooren, W., Loth, E., Murphy, D. G. M., Beckmann, C. F., Buitelaar, J. K., & the EU-AIMS LEAP group. (in press). Altered connectivity between cerebellum, visual, and sensory-motor networks in autism spectrum disorder: Results from the EU-AIMS Longitudinal European Autism Project. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.